FROM BIOLOGY TO THERAPY: THE CLL SUCCESS STORY

From Biology to Therapy: The CLL Success Story

Abstract.Chemoimmunotherapy has been the standard of care for patients with chronic lymphocytic leukemia (CLL) over the last decade.Advances in monoclonal antibody technology have resulted in the development of newer generations of anti-CD20 antibodies with improved therapeutic effectiveness.In parallel, our knowledge about the distinctive biologic

read more

Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells

ABSTRACT Candida albicans colonizes human mucosa, including the gastrointestinal tract, as a commensal.In immunocompromised Peeler patients, C.albicans can breach the intestinal epithelial barrier and cause fatal invasive infections.Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a), CEACAM5 (CEA), and CEACAM6 (CD66c) are im

read more

Longitudinal single-subject neuroimaging study reveals effects of daily environmental, physiological, and lifestyle factors on functional brain connectivity.

Our behavior and mental states are constantly shaped by our environment and experiences.However, little is known about the L-Citrulline response of brain functional connectivity to environmental, physiological, and behavioral changes on different timescales, from days to months.This gives rise to an urgent need for longitudinal studies that collect

read more

Quantification of Geometrical and Morphological Characteristics of Desiccation Crack and Shrinkage Behavior of Composite Clay Liner

Clay soil Food Processor Blades and their related irregular behavior such as shrinkage, swelling, desiccation cracks etc.are the main concern for the construction of composite clay liner (CCL) in waste landfill site.In this study, an investigation was conducted on a scaled model of prototype landfill liner to quantify both the geometrical and morph

read more

Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral

Increasing global temperatures due to climate change have resulted in respective increases in the severity and frequency of epizootics Urn Element around the globe.Corals in particular have faced rapid declines due to disease outbreaks.Understanding immune responses and associated potential life-history trade-offs is therefore a priority.In the aut

read more